Australia quick Brett Lee has suffered yet another injury setback after he was ruled out of the Commonwealth Break Series with a broken foot.

The veteran fast bowler suffered a fracture in his right foot when he was struck by a ball during Friday's eight-wicket defeat against India in the second Twenty20 international in Melbourne.

Cricket Australia confirmed that the injury will keep the 35-year-old on the sidelines for up to six weeks.

"Brett Lee sustained a fracture of his right foot when he was struck by a ball in the last over of his spell during the KFC T20 against India at the MCG on Friday night," Cricket Australia team doctor Trefor James said in a statement.

"He was able to complete the over, however the foot became more painful and swollen the following day.

"An x-ray has confirmed a fracture of the small toe and we now expect Brett will return to cricket in four-six weeks."

Australia will name a replacement after Sunday's opening CB Series match against India at the Melbourne Cricket Ground.