Batsman Hashim Amla has been ruled out of South Africa's second ODI against New Zealand at the De Beers Diamond Oval in Kimberley on Tuesday.

Amla sustained an injury to his right quadricep muscle during practice on Monday, casting his participation in the third and final match in Potchefstroom on Friday in doubt too.

"Hashim sustained the strain in his right quad during warm-ups on Monday, but continued training without much hindrance. He woke up on Tuesday with a severely stiff quad muscle and has been withdrawn from the playing XI," said team manager Dr Mohammed Moosajee.

"We will only be able to make a call on his availability for the final game after more assessment in the next few days."

The hosts will be also without captain AB de Villiers for the remainder of the three-match affair, which the Kiwis lead one-nil after a one-wicket win in Paarl.

De Villiers was dealt a two-match suspension after his side's over-rate contravention last week.

Batsman Faf du Plessis will lead the team in De Villiers' absence, while the left-handed David Miller has been called up to bolster the middle order.