Ireland were bowled out for a paltry 82 in their pursuit of Pakistan's 337 run total in the first ODI at Malahide in Dublin.
Sharjeel Khan had earlier struck an incredible 152 off just 86 balls, his innings included nine sixes and 16 fours.
Sahrjeel was assisted by an unbeaten 57 from Shoaib Malik and a debut half century from Mohammad Nawaz.
The match was restricted to 47 overs each, by rain, and during Pakistan's innings appeared to gallop along at a frantic pace, despite the visitors losing wickets on a frequent basis and Irish paceman Barry McCarthy picking up 4 for 62, the hosts were unable to put the brakes on the scoring rate.
The Ireland innings took on a similarly frantic pace but this time only in the sense that wickets tumbled at a regular rate.
Mohammad Amir started the party with his second ball as he bowled Paul Stirling with an inswinger for a duck.
Umar Gul joined in picking up the wickets of skipper William Porterfield (13), Ed Joyce (9) and Kevin O'Brien (4) in quick succession.
Imad Wasim ripped apart the lower order taking 5 for 14 in 5.4 overs to reduce Ireland to 82 all out.
Only Gary Wilson (21) and Andy McBrine (14*) offered anything that vaguely resembled resistance.