Seamer Pat Brown will miss the limited-overs leg of England’s tour of South Africa with a low back stress fracture.
The Worcestershire player, who made his England Twenty20 debut earlier this winter, sustained the problem while preparing to feature in the Big Bash League for Melbourne Stars.
Brown will not play again this winter and will now return to Worcestershire to start his rehabilitation programme.
An England statement added: “England will announce a replacement for the three-match ODI series and for the three IT20s against South Africa in due course.”
When the squads were announced, national selector Ed Smith, said: “These two squads were selected with an eye on the T20 World Cup in Australia in 2020.
“In the T20s, a number of players who were rested for the successful 3-2 victory in New Zealand return to the squad: Jos Buttler, Jofra Archer, Ben Stokes, Moeen Ali and Jason Roy.
“We want to expand the pool of players who can perform successfully for England, while also helping the team to peak for major tournaments.”
England ODI squad: Eoin Morgan (Middlesex, captain), Moeen Ali (Worcestershire), Jonny Bairstow (Yorkshire), Tom Banton (Somerset),
Pat Brown (Worcestershire), Sam Curran (Surrey), Tom Curran (Surrey), Joe Denly (Kent), Chris Jordan (Sussex), Saqib Mahmood (Lancashire), Dawid Malan (Yorkshire), Matthew Parkinson (Lancashire), Adil Rashid (Yorkshire), Joe Root (Yorkshire), Jason Roy (Surrey), Chris Woakes (Warwickshire).
England T20 squad: Eoin Morgan (Middlesex, captain), Moeen Ali (Worcestershire), Jofra Archer (Sussex), Jonny Bairstow (Yorkshire), Jos Buttler (Lancashire),
Pat Brown (Worcestershire), Sam Curran (Surrey), Tom Curran (Surrey), Joe Denly (Kent), Chris Jordan (Sussex), Dawid Malan (Yorkshire), Matt Parkinson (Lancashire), Adil Rashid (Yorkshire), Jason Roy (Surrey), Ben Stokes (Durham), Mark Wood (Durham).
Any return would have to be considered in the future with Yorkshire’s players and staff having taken wage cuts due to the pandemic.
The traditional method of spit-polishing to produce movement through the air has been deemed too great a risk of transmitting coronavirus.
The Lancastrian was fresh off some standout displays in the 2003 World Cup.
Hales lost his place in last year’s World Cup-winning squad after news of a second failed test for recreational drugs.
The Warwickshire all-rounder is one on 18 bowlers to be selected for personalised practice.
The West Indies are due to arrive on these shores first this summer.
Broad took part in an individual training session at Trent Bridge.
Clare Connor suggested England are considering hosting a Women’s Tri-Series also involving India and South Africa.
The designated bowlers, whose identitites have not been confirmed, will have their temperatures checked.