The 34-year-old batted throughout his side’s innings as West Indies chased down 170 with nine balls to spare.
FULL SCORECARD: Second T20I – West Indies beat India by eight wickets
Shivam Dube top scored for India (54) as Kesrick Williams and Hayden Walsh picked up two wickets a piece for the travelling West Indians.
In reply, Simmons was ably supported by Evin Lewis (40) and Nicolas Pooran (38), as the West Indies won by eight wickets in the 19th over.
The series is now level at 1-1 after Virat Kohli led his side to a six wicket victory in the opening game.
The third and final T20 takes place on Wednesday before the three ODI’s start on Sunday.
The Barbados Cricket Association president wanted the Windies head coach sacked after he went to his father-in-law’s funeral.
Holder did not bowl in the first internal warm-up match last week amid doubts over an ankle niggle.
The Gloucestershire wicketkeeper-batsman top-scored with a hard-earned 85 for Jos Buttler’s side.
Weekes scored scored 4,455 runs in 48 Tests and received his knighthood in 1995.
The Windies could call on Da Silva for the first Test against England following his display in this warm-up match.
It was ‘Team Stokes’ against ‘Team Buttler’ at the Ageas Bowl.
Intermittent showers have blighted the four-day contest at Emirates Old Trafford.
Duo – and others – aiming to impress in Southampton contest.