Willey had been involved throughout the four-year build-up to last year’s World Cup but was left out in favour of Jofra Archer.
Reece Topley also recalled four years after his last appearance.
England were tested a little more than they had been in the first game but easily got past Ireland in their second and final ODI winning by 85 runs.
England proved far too strong for Ireland in Bristol as they chased down the 127 runs they needed to win in just over twenty of the fifty allotted overs.
While Ireland have waited a long time to face England in England they may rue the timing of their first ever ODI series on the island.
Ireland fast bowler Tim Murtagh hopes Irish supporters can turn Lord's green when England host their neighbours for the first time at the historic stadium.
Kent and England batsman Sam Billings will return from the IPL to take the gloves during the forthcoming series against Ireland that begins in Bristol next week.